Sema4 Signal® Hereditary Cancer

Sema4 Signal Hereditary Cancer provides actionable information to guide better clinical care decisions

At Sema4, we believe that hereditary cancer testing should inform personalized cancer prevention and management strategies today, while also enabling patients and providers to benefit from the advances of tomorrow. That is why we perform germline testing on a medical exome platform, with biobanking of samples to enable future testing.

If you are a provider specializing in gynecology or IVF, click here to learn how our hereditary cancer solution can help your practice.

Sema4 Signal Hereditary Cancer is:


Seventeen testing panels, including a 107 gene universal panel and organ-specific sub-panels, run on medical exome data. Read more.


Proactive genetic counseling, best-in-class service, broad network coverage, and digital tools help make testing accessible for providers and patients. Read more.

Advanced & Accurate

Multiple methods of analysis ensure the highest detection rates, delivered via the Sema4 Traversa™ genomic platform with biobanking to support future testing. Read more.

Supportive of patients and providers



We can help providers:


For patients without a current cancer diagnosis


  • Detect inherited changes that increase an individual’s risk for certain cancers


  • Identify strategies to reduce the risk of developing cancer and aid early detection


>> Who should be tested? See here

For patients with a current cancer diagnosis


  • Build a personalized view of a patient’s disease by integrating germline testing with our somatic and informatics solutions


  • Identify strategies to reduce the risk of additional cancers


  • Determine the best treatment, including eligibility for therapies such as PARP inhibitors

For all patients independent of diagnosis


  • Identify family members with hereditary cancer risk and enable them to access testing


  • Leverage future clinical advances using biobanked medical exome data




Hereditary Cancer
Family History Questionnaire

Designed to help your patients assess their risk of hereditary cancer. For more information on how to implement this questionnaire within your practice, kindly fill out the contact form at the bottom of this page and someone from our team will be happy to help.

Start Questionnaire

Pre-test educational video

If you believe that a hereditary cancer test is right for your patient, then ask your patient to watch this informational video to learn more about the testing process.


Connect with us today

Kindly fill out the form below and we’ll schedule a time to discuss your needs. Or feel free to call us at 833-486-6260.